Biochemical Reagents
Cayman Chemical CTYP NatrIuretIc PeptID22
An endogenous peptide with diverse biological activities; a selective agonist of NPR2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively); stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM); (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock (25 μg/kg)
ABclonal Technology Phospho-PAK2-S20 Rabbit pAb
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
AdipoGen Pepstatin A, 26305-03-3, MFCD00060740, 100 mg
MF: C34H63N5O9, MW: 685.9, ≥98%, Appearance: White to off-white powder. Tight-binding, reversible, highly selective inhibitor of acid proteases (aspartyl peptidases), like pepsin, gastricsin, cathepsin E and D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Does not inhibit thiol proteases, neutral proteases or serine proteases. Widely used as a research tool in studies of protease mechanisms and biological functions. Solubilized gamma-secretase and retroviral protease inhibitor. Shows antibacterial, antifungal and antiparasitic activity. Suppresses p53-dependent apoptosis in lymphoid cells as well as TNFalpha-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Bachem Fmoc-Asp(OtBu)-(Dmb)Gly-OH
Fmoc-Asp(OtBu)-(Dmb)Gly-OH, 900152-72-9, C34H38N2O9, Mr 618.68, 1g. Dmb backbone protection completely prevents base-catalyzed aspartimide formation of the Asp(OtBu)-Gly motif during Fmoc-SPPS. The Dmb moiety is readily introduced by coupling this Fmoc-dipeptide. Contrary to the Hmb derivative, cyclic lactones cannot be formed during activation.
Meso Scale Discovery VPLEX Plus Ab Peptide PNL 6E10
The Meso Scale Discovery V-PLEX Plus Abeta Peptide Panel 1 (6E10) Kit is a multiplex immunoassay that measures Abeta38 Abeta40 and Abeta42 in human CSF and plasma samples It uses electrochemiluminescence detection technology and provides quantitative results in as little as 3 5 hours The kit includes a 96-well plate coated with capture antibodies detection antibodies and calibrators and controls needed to generate a standard curve and validate assay performance It allows sensitive reproducible and accurate measurement of Abeta peptides that are important biomarkers of Alzheimer s disease
Cayman Chemical SodIum StIbogluconate 1g
A pentavalent antimony derivative that is highly active against Leishmania amastigotes in macrophages
Cayman Chemical THUNDRTotal STAT6 TRFRET 2400
Sandwich TR-FRET immunoassay for semi-quantitative detection of Total STAT6 (both phosphorylated and non-phosphorylated) in cell lysates.
New England Biolabs, Inc. OneTaq 2X Master Mix with Standard Buffer – 100 reactions (50 µl vol)
OneTaq 2X Master Mix with Standard Buffer is an optimized blend of Taq and Deep Vent DNA Polymerases ideally suited to routine PCR applications from a variety of templates including pure DNA solutions, bacterial colonies, and cDNA products. The 3' to 5' exonuclease activity of Deep Vent DNA Polymerase increases the fidelity and robust amplification of Taq DNA Polymerase. The convenient master mix formulation contains dNTPs, MgCl2, buffer components and stabilizers, requiring only the addition of primers and DNA template for robust amplification.
Bachem Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) Trifluoroacetate, Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH, 1927927-42-1, C196H295N55O57S7, Mr 4558.30, 0.1mg. 6-FAM-AEEAc-ShK, ShK-F6CA. This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg1, selectively blocked the voltage gated T-lymphocyte K+ Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. It potently blocked Kv1.3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1.3 over Kv1.1 and other Kv channels.
Medchemexpress LLC Mal-(CH2)5-val-cit-pab-eribulin | 2130869-21-3 | MFCD00051944 | 99.8% | 1328.54 g/mol | C69H97N7O19 | 5 MG
Mal-(CH2)5-Val-Cit-PAB-Eribulin is a drug-linker conjugate intended for antibody-drug conjugate (ADC) research that links the anti-microtubule agent eribulin to a cleavable Mal-(CH2)5-Val-Cit-PAB spacer, producing a conjugate with potent antitumor activity for in vitro and preclinical studies.
- Drug-linker conjugate suitable for ADC research.
- Contains eribulin linked via a cleavable val-cit-pab spacer.
- Potent antitumor activity demonstrated in preclinical models.
- Molecular formula C69H97N7O19; molecular weight 1328.54 g/mol.
- High purity (99.82%) and supplied in low-milligram quantities for research use.
CPC Scientific DNP-Pro-Leu-Gly-Cys(Me)-His-Ala-DArg-NH2 (trifluoroacetate salt) 0.5MG
Efficient substrate for interstitial/vertebrate collagenase (MMP-1), stromelysin (MMP-3), gelatinases (MMP-2 and MMP-9) and punctuated metalloproteinase (MMP-7). ONE-LETTER SEQUENCE: Dnp-PLG-Cys(Me)-HA-DArg-NH2MOLECULAR FORMULA: C38H57N15O11S1MOLECULAR WEIGHT:932.03STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [145224-98-2], SYNONYMS: Dnp-Pro-Leu-Gly-Cys(Me)-His-Ala-D-Arg-NHRESEARCH AREA: CancerREFERENCES: J. Berman et al, JBC, 267, 1434 (1992)
AnaSpec Amylin (1-37), Rat, Mouse, Synthetic Peptide, Research Use Only, 0.5 mg
Amylin (1-37), rat, mouse is a synthetic peptide crucial for research on amylin's physiological roles without amyloid fibril formation. It differs from human amylin by six amino acids and serves as a potent tool for understanding islet amyloid polypeptide functions. This peptide supports various laboratory applications, ensuring quality with a purity of ≥95%.
Genscript Corporation Histone H3 His Human
Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells Featuring a main globular domain and a long N-terminal tail H3 is involved with the structure of the nucleosomes of the beads on a string structure Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones Histone H3 is an important protein in the emerging field of epigenetics where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes
CPC Scientific Cyclo(-Arg-Ala-Asp-D-Phe-Glu-) (ammonium salt) 1MG
This peptide is a negative control for the cyclo (-RGDfE) peptide. RGD peptides are modulators of cell adhesion, and are recognized by several members of the integrin family. This peptide has a low affinity binding to integrin peptides.SEQUENCE: Cyclo(-Arg-Ala-Asp-D-Phe-Glu-) (ammonium salt)ONE-LETTER SEQUENCE: Cyclo(-RADfE-)MOLECULAR FORMULA: MOLECULAR WEIGHT: 618.65STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [756500-23-9]SYNONYMS: RESEARCH AREA: CancerCATEGORY: Fibronectin and RGD Sequences »REFERENCES:Wester, H. et al. J. Nucl. Med. 46, 1940 (2005)Janssen, M. et al. Canc. Res. 62, 6146 (2002)SKU(s): RGDP-002A, RGDP-002B, RGDP-002C
Carbosynth LLC. Boc-Gln-Ala-Arg-MCA (5 mg vial), 1ea, MW: 630.69, Molecular formula: C29H42N8O8, CAS# 113866-20-9
This item has a minimum order quantity of 2 per supplier requirements
Synonyms: t-Butyloxycarbonyl-L-Glutaminyl-L-Alanyl-L-Arginine 4-Methyl-Coumaryl-7-Amide, Boc-Gln-Ala-Arg-AMC, Boc-QAR-AMC, Boc-QAR-MCA, Purity: , Grade A, Application: Substrate for Trypsin, Storage Temperature: -20C, References: S. Kawabata, T. Miura, T. Morita, H. Kato, K. Fujikawa, S. Iwanaga, K. Takada, T. Kimura, and S. Sakakibara, Eur. J. Biochem., 172, 17 (1988).